RESEARCH
DISAP-INSERM
The DisAP group's objective is to promote multidisciplinary health research on psychiatric and cognitive disabilities to provide evidence to guide health decisions and the choice of therapeutic strategies in real-life (ecological) situations. The final aim is to improve the health, capacities, and community integration of people with disabilities. The team's project is framed from the perspective of Health Outcomes and Health Services Research and implementation science.
The group's main areas of expertise include severe and persistent mental disorders (schizophrenia and bipolar disorders) and head injury/stroke.
The team is structured around 4 main methodological axes:
Improving diagnostic (e.g., developing tools for measuring cognitive impairment, disability, and functional consequences of disorders, predicting future outcomes, and supporting compensatory measures). We are particularly interested in improving the assessment of social cognition, metacognition (introspective accuracy) functional capacity, and everyday functioning in severe and persistent mental disorders and traumatic brain injuries.
Therapeutic innovations (in particular in the field of cognitive rehabilitation and remediation, development and evaluation of innovative care),
Study of the healthcare pathways of the populations of interest (setting up clinical cohorts to study the determinants of disabilities and analyzing existing databases),
Evaluation of health interventions and care devices for the populations of interest (measures of impact and efficiency indicators).
Lab history
DisAP is the continuation of our former team EA 4047 HANDIReSP at Versailles Saint-Quentin-En-Yvelines University. We extend the founding work of Pr Hardy-Baylé about Theory-of-Mind deficit and disorganization in schizophrenia.
Impact
Our work has had several major impacts. In the field of cognitive neuropsychiatry, we contributed to the acknowledgment of deficits in theory of mind as an associated feature supporting the diagnosis of schizophrenia in the last version of the Diagnostic and Statistical Manual of mental disorders (DSM-5). Our works have also led to the development of a cognitive remediation technique for individuals with schizophrenia which is employed by a dozen of teams in France.
ECPDS_english.docxEvaluation of psychiatric disability
We have created and evaluated several scales to help the clinician in evaluating psychiatric disability in severe and persistent mental disorders. ECDPS - Evaluation of Cognitive Processes involved in Disability in Schizophrenia (in French: EPHP - Echelle d’évaluation des Processus cognitifs impliqués dans le handicap Psychique dans la schizophrénie) is a scale measuring psychiatric disability, which can be filled out by anyone in the immediate circle of the patient, be it a family member, a close friend, or a staff member (social worker, care worker, etc.). V-MSEQ (Versailles Metacognitive Strategies Evaluation Questionnaire) is an auto-questionnaire that assesses the use of metacognitive and help-seeking strategies in three key domains of impaired daily functioning in schizophrenia.
Clinical cohorts in psychiatry
We participate in three nationwide cohorts of the Fondamental centers of expertise: FACE-BD (bipolar disorders), FACE-SZ (schizophrenia spectrum disorders), and FACE-Asp (Asperger syndrom). We investigated several clinical dimensions in these longitudinal cohorts, such as neurocognition, social cognition, metacognition, disorganization, clinical insight, functioning and quality of life.
METACTION
MetAction is an ERC funded project led by Nathan Faivre, a CNRS scientist at LPNC in Grenoble. We collaborate on the workpackage dedicated to understanding metacognitive deficit in schizophrenia.
extrait_entretien_SIVIPSY.mp4SIVIPSY
SIVIPSY is a pedagogical research project in health sciences involving a serious game to teach psychiatry. It involves an emotionally reactive 3D avatar allowing a virtual simulation of a psychiatric interview. It is developed with Pr Jean-Claude Martin, at the LISN.